Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Keith Choate
PO Box 208059, 333 Cedar Street, New Haven, CT 06520-8059
Tanzania
Case Report
Somatic Mosaicism in Blaschkolinear Inflammatory Disorders
Author(s): Nicholas Theodosakis, Lauren Levy, Shawn Cowper, Rossitza Lazova, Lisa Kugelman, Amanda Zubek and Keith ChoateNicholas Theodosakis, Lauren Levy, Shawn Cowper, Rossitza Lazova, Lisa Kugelman, Amanda Zubek and Keith Choate
Linear lichen planus (LP) is a rare dermatologic disease in which lichenoid lesions conform to a blaschkolinear distribution, most commonly on the extremities. Linear discoid lupus erythematosus (DLE) is a cutaneous manifestation of lupus that also conforms to Blaschko’s lines. Blaschkolinear disorders have been shown to result from somatic mosaicism, most recently in nevus sebaceus, epidermal nevi, and syringocystadenoma papilliferum. In linear LP and DLE, presentation of papules along Blaschko’s lines suggests that these disorders can result from keratinocytic genetic mosaicism. Their onset later in life suggests that a secondary trigger is necessary to drive inflammatory reactions to these linear lesions. To date causative mutations have not be identified. We report 2 cases of linear lichen planus and 1 case of linear discoid lupus erythematosus, all histologically conf.. View More»
DOI:
10.4172/2155-9554.1000356