Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Keiichi Hiramoto
3500-3 Minamitamagakicho, Suzuka, Mie 513-8670
Japan
Research Article
Mild Exercise Suppresses Exacerbation of Dermatitis in NC/Nga Mice: Correlation with b-endorphin Levels
Author(s): Keiichi Hiramoto, Eisuke F Sato, Hiromi Kobayashi, Satoshi Yokoyama and Kazuya OoiKeiichi Hiramoto, Eisuke F Sato, Hiromi Kobayashi, Satoshi Yokoyama and Kazuya Ooi
Atopic dermatitis (AD) is known to be effected by mild or strong stress. However, the mechanism underlying this phenomenon is unclear. This study analyzed the mechanism(s) responsible for the influence of different levels of stress on AD. Specific pathogen-free (SPF) and conventional NC/Nga mice were used for the studies. Conventional mice, but not SPF mice, spontaneously develop dermal symptoms similar to that of patients with AD. Two types of stress, mild (20 m/min for 60 min) or strong (25 m/min for 90 min) exercise were applied using a treadmill four times per day. The symptoms of the conventional group were strongly exacerbated by strong exercise but ameliorated by mild exercise. The plasma concentration of β-endorphin was increased by mild exercise. The transepidermal water loss of strong exercise in the conventional mice was higher than that of the no-exercise conventional.. View More»
DOI:
10.4172/2155-9554.1000180