Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Kazuto Taniguchi
5-1-1 Nabeshima, Saga 849-8501
Japan
Research Article
Blockade of Interleukin-33 Attenuates Allergic Contact Dermatitis in Model Mice: Possible Mechanism via Eosinophil Infiltration
Author(s): Kazuto Taniguchi, Shuichi Yamamoto, Emiko Hitomi, Yukiko Inada, Takashi Sugioka and Yuhei HamasakiKazuto Taniguchi, Shuichi Yamamoto, Emiko Hitomi, Yukiko Inada, Takashi Sugioka and Yuhei Hamasaki
Background: Interleukin (IL)-33, a novel member of the IL-1 family, is mainly produced by epithelial cells and endothelial cells. Effects of IL-33 on allergic diseases have been reported. Allergic contact dermatitis is a clinical form of contact hypersensitivity that involves a delayed-type hypersensitivity reaction. We previously reported that IL-33 is induced by tumor necrosis factor-alpha and interferon-gamma in keratinocytes and plays a critical role in allergic contact dermatitis. However, the mechanism underlying how IL-33 is involved in the pathogenesis of allergic contact dermatitis is not fully understood. We investigated the role of IL-33 in allergic contact dermatitis using model mice.
Methods: Allergic contact dermatitis model mice were generated. Epidermal thickness and eosinophil infiltration in the dermis were evaluated by his.. View More»
DOI:
10.4172/2155-9554.1000183