Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
+44 1223 790975
ISSN: 2167-7700
+44 1223 790975
Kazuhiro Nagao
Graduate School of Medicine,
1-1-1, Minami-Kogushi, Ube, 755-0046, Yamaguchi
Japan
Research Article
Risk Stratification Model to Predict High-Risk Patients for Adjuvant
Chemotherapy in Upper Urinary Tract Urothelial Cancer
Author(s): Kazuhiro Nagao, Hideyasu Matsuyama, Kiyohide Fujimoto, Haruhito Azuma, Hiroaki Shiina, Shigeru Sakano, Yoshihiro Tatsumi, Teruo Inamoto and Hiroaki YasumotoKazuhiro Nagao, Hideyasu Matsuyama, Kiyohide Fujimoto, Haruhito Azuma, Hiroaki Shiina, Shigeru Sakano, Yoshihiro Tatsumi, Teruo Inamoto and Hiroaki Yasumoto
Objective: Optimal patient selection for adjuvant chemotherapy has not been clarified in upper urinary tract urothelial cancer (UTUC). We aimed to develop a risk model to select candidates for adjuvant chemotherapy after radical nephroureterectomy (RNU).
Methods: A retrospective review of 936 patients with UTUC between 1995 and 2015 who received ≥ 2 cycles of platinum-based adjuvant chemotherapy after RNU (n=213) or surgery alone (n=723) was conducted in collaborative institutions. Risk factors for cancer-specific mortality were extracted using the proportional hazard model. The survival benefit in high-risk patients was compared between the groups.
Results: At a median follow-up of 1006 days (34 months), disease recurrence, cancer-specific mortality, and allcause mortality were noted in 253 (27.5%), 206 (22.0%).. View More»
DOI:
10.4172/2167-7700.1000221