Journal of Developing Drugs

Journal of Developing Drugs
Open Access

ISSN: 2329-6631


Karthikeyan M

Karthikeyan M
School of Pharmacy and Medical Sciences,
Pacheribari, Jhunjhunu-333 515, Rajasthan

  • Review Article
    In-vivo Animal Models and In-vitro Techniques for Screening Antidiabetic Activity
    Author(s): Karthikeyan M, Balasubramanian T and Pawan KumarKarthikeyan M, Balasubramanian T and Pawan Kumar

    Diabetes mellitus is a group of metabolic disorder, is characterized by absolute by lack of insulin and resulting in hyperglycemia. About 2.8% of global populations are affected by Diabetes mellitus. The search for new drug with new properties to treat the disease is still in progress. The current review have made an attempt to bring together all reported models and advanced techniques. Experimentally diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic manipulations. The various in vitro techniques includes: In-vitro studies on insulin secretion, In-vitro studies on glucose uptake, Studies using isolated pancreatic islet cell lines, Assay of Amylase Inhibition and Inhibition of α-Glucosidase Activity. Experimental induction of diabetes mellitus in animal models and in vitro techniques are essentials for the.. Read More»
    DOI: 10.4172/2329-6631.1000153

    Abstract PDF

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