GET THE APP

Journal of Developing Drugs

Journal of Developing Drugs
Open Access

ISSN: 2329-6631

+44 1478 350008

Kamble Sharad K

Kamble Sharad K
Tatayasaheb Kore College of Pharmacy,
Warananagar, Kolhapur, Maharashtra
India

Publications
  • Research Article
    Design and Development of Fast Dissolving Tablet of Gliclazide
    Author(s): Kamble Sharad K and Shinde Sunita SKamble Sharad K and Shinde Sunita S

    In the present study, Gliclazide is a second-generation sulfonyl urea derivative used to treat non-insulin dependent diabetes mellitus. The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So, an attempt was made to enhance the solubility of gliclazide by solvent evaporation technique. A significant enhancement of gliclazide dissolution rate will be obtained using by using suitable techniques. In this PVP-k30, polyethylene glycol and soluplus were mixed with the drug in different ratios (1:1, 1:3) and prepare P1, P2, PE1, PE2, S1 and S2 solid dispersion batches. The optimized solid dispersions P1 were further kneaded with suitable proportions of super disintegrants such as; Cross carmellose and Sodium starch glycolate. Dissolution profile will show decrease amount of drug release at specified ti.. View More»
    DOI: 10.4172/2329-6631.1000177

    Abstract PDF

Relevant Topics

Top