Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
+44 1223 790975
ISSN: 2329-6488
+44 1223 790975
Jurg Ott
Tanzania
Research Article
Self-Administration of Oxycodone by Adolescent and Adult Mice Differentially Affects Hypothalamic Mitochondrial Metabolism Gene Expression
Author(s): Yong Zhang, Molly Deutsch-Feldman, Michele Buonora, Adam J Brownstein, Keiichi Niikura, Ann Ho, Jurg Ott and Mary Jeanne KreekYong Zhang, Molly Deutsch-Feldman, Michele Buonora, Adam J Brownstein, Keiichi Niikura, Ann Ho, Jurg Ott and Mary Jeanne Kreek
Objective: Illicit prescription drug use among adolescents is a pressing public health concern: 12% of high school students report using prescription opioids with many progressing to use heroin. However, little is known about the effects of these drugs on the adolescent brain compared to the adult brain. This study examined the effect of adolescent oxycodone self-administration on gene expression specifically related to mitochondrial energy metabolism in the hypothalamus as the hypothalamus is involved in the regulation of feeding, reproduction and stress-induced drug seeking behavior.
Methods: Adolescent and adult mice self-administered oxycodone (0.25mg/kg/infusion) or served as yoked saline controls 2 hours daily for 14 days. The hypothalamic mRNAs were analyzed with qPCR using a commercially available “mitochondrial energy metaboli.. View More»
DOI:
10.4172/2329-6488.1000153