Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Juma KK
P.O. Box 43844-00100, Nairobi
Kenya
Research Article
Protective Effects of Urtica dioica and Cimetidine® on Liver Function Following Acetaminophen Induced Hepatotoxicity in Mice
Author(s): Juma KK, Maina SG, Muriithi JN, Mwangi BM, Mworia KJ, Mwonjoria MJ, Ngeranwa JN and Mburu NDJuma KK, Maina SG, Muriithi JN, Mwangi BM, Mworia KJ, Mwonjoria MJ, Ngeranwa JN and Mburu ND
Studies have demonstrated that Urtica dioica promotes regeneration of the liver cells following damage by carbon tetrachloride. This study investigated the effects of Urtica dioica on liver function following acetaminophen overdose. Mice were divided into eight groups of ten each. Acetaminophen at 250 mg/kg and 500 mg/kg significantly (p<0.05) reduced red blood cells, neutrophils and albumins while mean corpuscular hemoglobin, lymphocytes, alanine amino transferase, aspartate amino transferase, prothrombin time and liver pathology were increased. Lactate dehydrogenase was significantly reduced in acetaminophen 250 mg/kg while acetaminophen 500 mg/kg significantly increased alkaline phosphatase and total bilirubin. Even after exposure to acetaminophen toxicity, mice pre-treated with Urtica dioica retained the following parameters within normal range: neutrophils, lymphocytes, alanin.. View More»
DOI:
10.4172/2329-6631.1000130