Journal of Osteoporosis and Physical Activity
Open Access
ISSN: 2329-9509
+44 1478 350008
ISSN: 2329-9509
+44 1478 350008
John N. Nanas
Greece
Research Article
Bone Metabolism in Chronic Heart Failure
Author(s): Panagiotis Zotos, Elisabet Kaldara, Christos Kapelios, Vasilios Sousonis, Emmeleia Nana, Varvara Agapitou, Stavros Dimopoulos, Christos D Kontogiannis, Athanasios Chalazonitis, Zafiria Margari, Eleni Karga, John V. Terrovitis and John N. NanasPanagiotis Zotos, Elisabet Kaldara, Christos Kapelios, Vasilios Sousonis, Emmeleia Nana, Varvara Agapitou, Stavros Dimopoulos, Christos D Kontogiannis, Athanasios Chalazonitis, Zafiria Margari, Eleni Karga, John V. Terrovitis and John N. Nanas
Purpose: Chronic Heart Failure (HF) is complicated by bone loss and osteoporosis, which have been linked to hyperparathyroidism. We studied the bone metabolism and possible role of cytokines in patients suffering from HF.
Methods and results: We measured bone alkaline phosphatase (BALP), C-telopeptides of type I collagen (β-CTx) and Interleukin-(IL) 6 in 60 men, 56 ± 11 years of age, suffering from chronic HF, and in 13 age-matched men free from HF. We also measured total body and femoral bone densitometry and parathyroid hormone (PTH). The β-CTx concentrations were significantly higher in men with than in men without HF. The concentrations of BALP (12.4 ± 4.9 vs. 9.9 ± 3 μg/l; P=0.03) and β-CTx (0.67 ± 0.35 vs. 0.33 ± 0.21 ng/ml; P<0.001) were significantly higher in patients in New York Heart A.. View More»
DOI:
10.4172/2329-9509.1000121