Journal of Clinical & Experimental Dermatology Research
Open Access

Jinah Kim

Publications

• Research Article
  Evaluation of Invasive Squamous Cell Carcinoma, Seborrheic Keratosis and Verruca Vulgaris in Superficial Shave Biopsies using p16, p53, p63, and PHLDA1 Immunohistochemistry
  Author(s): Ryanne A Brown and Jinah Kim Ryanne A Brown and Jinah Kim
  
  Occasionally, the distinction between malignant and benign is challenging in superficial shave biopsies of squamoproliferative lesions. This phenomenon is compounded by the increasing prevalence of conditions encountered that weaken the immune system, such as chemotherapy, immune deficiency diseases, and antirejection medications for organ transplantation that have all been shown to increase the risk of the development of squamous cell carcinoma that are sampled. We collected 30 cases (10 invasive SCC, 10 SK and 10 VV) and performed immunohistochemical staining using a panel approach composed of markers important for proliferation and cell cycle, including Ki-67, p16, p53, and PHLDA1. The results demonstrate that the invasive SCC group was enriched for high PHLDA1 (80% with PHLDA1 score=3, 100% with PHLDA1 score ≥ 2) and high p53 (50% of SCC with p53 score ≥ 2 vs. 60% of SK and .. View More»
  DOI: 10.4172/2155-9554.1000352

  Abstract PDF

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