Journal of Infectious Diseases & Preventive Medicine
Open Access
ISSN: 2329-8731
+44 1300 500008
ISSN: 2329-8731
+44 1300 500008
Jennifer R DiBiagio
Tanzania
Commentary
Alzheimer’s disease: A Commentary on Biofilms, Beta Amyloid and their Locations
Author(s): Jennifer R DiBiagio, Suresh G Joshi and Herbert B AllenJennifer R DiBiagio, Suresh G Joshi and Herbert B Allen
The pathological study of brains affected by Alzheimer’s disease (AD) has shown the presence of spirochetal infection. These bacteria produce a detectible biofilm as a defense mechanism, impenetrable by both the immune system and antibiotic medications. The failure of the innate immune system at the site of biofilm deposition ultimately leads to the pathognomonic beta-amyloid (Aβ) plaques of AD at the exact same location as visualized by immunological staining. Furthermore, recent studies show that senile plaques are partially composed of bacterial Aβ in addition to that of the host. The bacterial and neuropathology similarities continue with similar staining results using all of the following: silver impregnation techniques, green thioflavin S fluorescence, anti-AβPP, and anti-AβPP antibodies. TUNEL assay of senile plaques further support the DAPI visualizat.. View More»
DOI:
10.4172/2329-8731.1000140