Chemotherapy: Open Access
Open Access

Irene Marchesi

Publications

• Short Communication
  SFK Inhibitors as New Strategy for RMS Treatment
  Author(s): Luigi Bagella and Irene MarchesiLuigi Bagella and Irene Marchesi
  
  A new study investigates about the activity of a new SFK inhibitor in RMS. SI221 is a pyrazolo [3,4-d] pyrimidine derivative able to reduce both apoptosis and differentiation in eRMS and aRMS. SFKs are frequently overexpressed in RMS and their inhibition can be a good strategy for RMS treatment. Rhabdomyosarcoma (RMS) represents approximately half of the total pediatric soft tissue sarcoma (STS), slightly more frequent in males but equally distributed across racial groups [1]. RMS is characterized by the expression of genes involved in the early myogenesis which fail to complete differentiation and cell cycle arrest [2]. It can be divided into 2 major histological subtypes: embryonal (eRMS), mostly found in childhood, and alveolar (aRMS) common in both children and adults [1]. .. View More»
  DOI: 10.4172/2167-7700.1000189

  Abstract PDF

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