Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Ichiro Katayama
Graduate School of Medicine,
2-2 Yamada-oka, Suitashi, Osaka, Japan 565-0871
Japan
Review Article
Platelet Activation as a Possible Indicator of Disease Activity in Chronic Urticaria: Link with Blood Coagulation and Mast Cell Degranulation
Author(s): Ichiro Katayama, Saki Matsui and Hiroyuki MurotaIchiro Katayama, Saki Matsui and Hiroyuki Murota
Background: Much attention has been paid to activation of the blood coagulation cascade during urticaria attacks. Elevated levels of plasma D-dimer and prothrombin fragment 1+2 have been reported. The final product of the coagulation cascade, thrombin, may induce mast cell degranulation, complement fragmentation, or platelet-activating factor expression. However, the involvement of platelets in urticaria is poorly understood.
Methods: We examined the relationship between disease activity and plasma levels of platelet factor IV, β-thromboglobulin, D-dimer, and prothrombinfragment (Fr) 1+2 in 23 patients with chronic urticaria.
Results: We observed elevated plasma levels of platelet factor IV (13/23) and β-thromboglobulin (15/23) in patients with chronic urticaria that returned to normal after anti-histamine th.. View More»
DOI:
10.4172/2155-9554.1000194