Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
+44 1223 790975
ISSN: 2167-7700
+44 1223 790975
Hsia CC
London Health Sciences Centre Room,
E6-219A, Victoria Hospital, 800 Commissioners Road, East London, Ontario, N6A 5W9
Canada
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Chronic Lymphocytic Leukemia with Leptomeningeal Involvement
Author(s): Bharath V and Hsia CCBharath V and Hsia CC
An 80 year old woman with chronic lymphocytic leukemia (CLL) developed lymphocytosis with symptomatic anemia and axillary lymphadenopathy two years after her diagnosis. Her white count was 27.9 × 109/L with a lymphocyte count of 4.185 × 109/L and hemoglobin 89 g/L. Initial flow cytometric immunophenotyping confirmed a monoclonal B-cell population positive for CD19/CD5, dim CD20, CD23, and expressing dim kappa light chains. Repeat peripheral blood flow cytometry revealed the same monoclonal B-cell population, and an axillary node biopsy was consistent with CLL. Chlorambucil was initiated, but discontinued after two cycles due to multiple side effects. A month later, the patient presented with acute onset upper extremity weakness. A lumbar puncture and examination of cerebrospinal fluid revealed a mixed population of pleomorphic lymphocytes with the same immunophenotype as t.. View More»
DOI:
10.4172/2167-7700.1000I102