GET THE APP

Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 20 3868 9735

Holly Anderton

Holly Anderton

Australia

Publications
  • Case Report
    Cutaneous Lichen Planus Induced by Secukinumab
    Author(s): Brent J Doolan, Holly Anderton, Michael Christie and Con DolianitisBrent J Doolan, Holly Anderton, Michael Christie and Con Dolianitis

    Lichen planus (LP) is a chronic mucocutaneous disease, characterised by an inflammatory immune response with sub-epithelial infiltration of T lymphocytes causing basal epithelial cell damage. Secukinumab is a monoclonal antibody that blocks IL-17A; which is the primary cytokine of Th17 cells involved in the aetiology of inflammatory skin diseases such as psoriasis. Secukinumab has been linked to induction of oral LP, but never directly to cutaneous LP. We report the first case of drug-induced cutaneous LP in the setting of secukinumab for treatment of chronic plaque psoriasis. A 56-year-old man with chronic plaque psoriasis presented with a 2-month history of violaceous and pruritic, thickened plaques on his bilateral lower limbs and buttocks in the setting of secukinumab use for psoriasis. Histological analysis showed a band-like lymphocyte inflammatory infiltrate just beneath the ep.. Read More»
    DOI: 10.4172/2155-9554.1000437

    Abstract PDF

Relevant Topics