Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Hideki Maejima
Department of Dermatology,
1-15-1 Kitasato, Sagamihara, Kanagawa
Japan
Research Article
The Distribution of Anti-NKG2A and NKG2C Positive Cells in Lichen Palnopilaris
Author(s): Hideki Maejima, Tomonori Taniguchi, Yasuyuki Amoh, Shiro Niiyama and Kensei KatsuokaHideki Maejima, Tomonori Taniguchi, Yasuyuki Amoh, Shiro Niiyama and Kensei Katsuoka
Background: Lichen planopilaris (LPP) is a rare alopecia disorder. The histopathological features of LPP may resemble discoid lupus erythematosus (DLE). However, LPP usually lacks interfollicular inflammation, which differentiates it from DLE.
Methods: Skin biopsies were taken from subjects with early-stage LPP and DLE. The biopsies were evaluated for anti-CD56, anti-CD94, and anti-NKG2A/C/D-positive cells; the results were compared among two diseases.
Results: Anti-CD4, -CD8, and -CD94 positive cells mainly infiltrate the perifollicular dermis from the infundibulum to the hair isthmus in patients with LPP. Anti-CD56 and-NKG2C-positive cells were observed in the hair isthmus and bulge area (LPP) and in the infundibulum (DLE). In LPP, anti-NKG2A-positive cells were mostly seen in the infundibulum (p<0.05), but th.. View More»
DOI:
10.4172/2155-9554.1000167