Drug Designing: Open Access
Open Access
ISSN: 2169-0138
+19473334405
ISSN: 2169-0138
+19473334405
Hector H Palacios
Tanzania
Research Article
Mitochondria Specific Antioxidants and their Derivatives in the Context of the Drug Development for Neurodegeneration and Cancer
Author(s): Gjumrakch Aliev, Hector H Palacios, Pablo Cacabelos and Ramon CacabelosGjumrakch Aliev, Hector H Palacios, Pablo Cacabelos and Ramon Cacabelos
Neurodegeneration and cancer are fast becoming the leading causes of age-associated disability, dementia and ultimately death worldwide. Although oxidative stress has been intensely studied, little analysis has been done in chronic oxidative stress-induced mitochondrial models. In this regard, DNA-overproliferation and/or deletion initiate mitochondrial deregulation causing energy failure, which has been implicated in the pathogenesis of Alzheimer’s disease (AD), tumor growth, and metastasis. In this regard, decline in mitochondrial normal homeostasis during the development and maturation of the neurodegeneration, tumor growth, and/or metastases is characterized by tissue and cellular oxygen deficiency, which leads to subcellular energy defects. In addition, the overexpression of the cascades initiates the formation and release of large amounts of reactive free radicals [mainly .. Read More»
DOI:
10.4172/2169-0138.1000103