Journal of Alcoholism & Drug Dependence
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• Research Article
  Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors “Central” and “Peripheral” Types in the Cerebral Cortex of “Heavy Drinkers” Rats.
  Author(s): TV Shushpanova, AV Solonskii, NA Bokhan, TP Novozheeva, VV Udut, GA Arbit and VD Filimonov TV Shushpanova, AV Solonskii, NA Bokhan, TP Novozheeva, VV Udut, GA Arbit and VD Filimonov
  
  Objective: studies of anticonvulsants have a stimulating effect on neuronal receptors; in particular GABAA/ benzodiazepine receptor complex (GABAA/BzDR) can be the basis for the development of new approaches to the treatment of alcohol withdrawal syndrome (AWS) and alcohol addiction. Benzodiazepine receptors (BzDRs) of the cerebral cortex of Wistar male rats with a different preference for alcohol and BzDRs in the brain “heavy drinkers” rats, treated with original anticonvulsant meta-chloro-benzhydryl urea (m-ch-BHU) were examined in these study. Materials and methods: Wistar male rats (n=250) were used in an experimental model of alcoholism. Properties of the BzDRs of the “central” (synaptic) and “peripheral” (mitochondrial) type were exa.. View More»
  DOI: 10.4172/2329-6488.1000234

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