Chemotherapy: Open Access
Open Access

Elżbieta Pels

Publications

• Short Communication
  Concentration of Tumour Necrosis Factor-Alpha in Saliva of Patients with Acute Lymphoblastic Leukaemia in Relation to Oral Mucositis during Chemotherapy
  Author(s): Elżbieta PelsElżbieta Pels
  
  Abstract Purpose: Ulceration in the oral cavity caused by stomatotoxic chemotherapy is painful and restricts oral administration of drugs. The study objective was to assess concentration of tumour necrosis factor-alpha (TNF-?) cytokine in saliva of patients with acute lymphoblastic leukaemia and to assess the occurrence of oral mucositis during chemotherapy. Methods: The study included 78 children with ALL in followed three examinations and a control group - 78 healthy children. In the group of patients with ALL was conducted the clinical study to assess oral mucosa based on the five-grade WHO classification of oral mucositis. Two hours after morning meal unstimulated saliva samples were taken and TNF-? was determined by TNF-? human EIA Results: Saliva TNF-? concentration determined in the group of children with ALL in examination 1 ranged 4.16?135.01pg/ml. Mean saliva TNF-? concentr.. View More»
  DOI: 10.4172/2167-7700.1000169

  Abstract PDF

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