Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
ISSN: 2155-9554
Díaz-Lozano Marisol
Mexico
Research Article
Chronic Actinic Damage in Pigmented and Depigmented Skin of Hispanic Patients with Vitiligo: Clinical and Histological Differences
Author(s): Maria Teresa Garcia-Romero, Ochoa-Sánchez Patricia Esmeralda, Díaz-Lozano Marisol, Toussaint-Caire Sonia and Lacy-Niebla Rosa MariaMaria Teresa Garcia-Romero, Ochoa-Sánchez Patricia Esmeralda, Díaz-Lozano Marisol, Toussaint-Caire Sonia and Lacy-Niebla Rosa Maria
Vitiligo is a common depigmentary disorder, with loss of epidermal Melanocytes as its hallmark. This absence of melanin hypothetically makes skin more susceptible to Chronic Actinic Damage (CAD) and skin cancer development. However, various studies have shown no increased incidence of skin cancer and some point to decreased actinic damage in skin with vitiligo. We studied 14 patients with vitiligo and analyzed clinical and histological markers of chronic actinic damage both in depigmented skin with vitiligo and in normal skin. We found fewer markers of clinical CAD in depigmented skin than in normally pigmented skin. When we analyzed histological, we found that in most patient’s depigmented skin had increased hyperkeratosis, which is a previously reported finding, as well as atrophy, elastosis and telangiectasias. There are various hypotheses to explain these findings. Further s.. View More»
DOI:
10.4172/2155-9554.1000154