Journal of Developing Drugs
Open Access

David J Mastropietro

Publications

• Research Article
  Commercial Abuse-Deterrent Dosage Forms: Clinical Status
  Author(s): David J Mastropietro and Hossein OmidianDavid J Mastropietro and Hossein Omidian
  
  Abuse of prescription medications is being combated with the advent of novel formulations designed to prevent or discourage tampering and misuse. The ability of these abuse-deterrent and tamper-resistant formulations to impact abuse, and the test methods used to determine their lowered abuse potential is becoming more important. There are three main reasons for the need to access these formulations, a) to determine if a formulation itself can impact abuse of a product, b) for standardized methods that can be used to support product labeling, and c) to evaluate both new and generic products for tamper-equivalence. The object of this review is to provide an overview and evaluation of the various types of premarketing tamper and abuse studies performed both in-vitro and by experienced abusers when evaluating a product’s deterrence to abuse. To find and assess abuse liability studie.. View More»
  DOI: 10.4172/2329-6631.1000103

  Abstract PDF

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