Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Dario Antolin-Amerigo
Allergy Division, Hospital Universitario Ramon y Cajal, Madrid,
Spain
Research Article
In-vitro Tests Suitability in Severe Systemic Reaction due to Several Drugs
Author(s): Dario Antolin-Amerigo, Maria Luisa Sanz, Lucienne Costa-Frossard França, Teresa Caballero Molina, Pernila Tirado Zambrano, Rosario Carrillo Gijón, Ingrid Rocío Aguayo Leiva and Belen de La Hoz CaballerDario Antolin-Amerigo, Maria Luisa Sanz, Lucienne Costa-Frossard França, Teresa Caballero Molina, Pernila Tirado Zambrano, Rosario Carrillo Gijón, Ingrid Rocío Aguayo Leiva and Belen de La Hoz Caballer
Background: Toxic-Epidermal-Necrolysis might be a severe delayed reaction to drugs, so in-vitro assessment could be suitable. To date there are not validated diagnostic procedures for such cases. Methods: A 33 year-old female suffering from Multiple-Sclerosis (MS) was receiving Beta1a-Interferon from the last 2.5 months, Deflazacort 1 month and Ibuprofen occasionally. She consulted the emergency department due to confluent dianiform maculae, denudating blisters and subsequent systemic symptoms which led to toxic epidermal necrolysis after skin biopsy result. Cyclosporine, Prednisone, Zinc-Sulfate baths and complete discontinuation of implicated medication achieved total symptom relief. A Basophil Activation Test (BAT) and Lymphocyte-Transformation- Test (LTT) were carried out using Beta1aInterferon, Deflazacort and Ibuprofen at different dilutio.. View More»
DOI:
10.4172/2155-9554.S2-005