Drug Designing: Open Access

Drug Designing: Open Access
Open Access

ISSN: 2169-0138


Chitlange NR

  • Research Article
    Sensitive Quantitative Predictions of mhc Binding Peptides and Fragment Based Peptide Vaccines From Trichinella spiralis
    Author(s): Gomase VS and Chitlange NRGomase VS and Chitlange NR

    Trichinella spiralis is a nematode parasite, occurring in rats, pigs, bears and humans, and is responsible for the disease trichinosis. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Trichinella spiralis are important determinant for protection of host form parasitic infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 439 amino acids, which shows 432 nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Trichinella spiralis. .. Read More»
    DOI: 10.4172/2169-0138.1000101

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