Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
+44 1223 790975
ISSN: 2167-7700
+44 1223 790975
Chang Jiang
IR Iran
Research Article
A Potential Administration-time Dependent Effect of Bevacizumab in
Improving Overall Survival and Increasing Metastasis in Metastatic
Colorectal Cancer
Author(s): Bei Zhang, Wenzhuo He, Feifei Zhou, Guifang Guo, Chang Jiang, Chenxi Yin, Xuxian Chen, Huijuan Qiu, Yuming Rong and Liangping XiaBei Zhang, Wenzhuo He, Feifei Zhou, Guifang Guo, Chang Jiang, Chenxi Yin, Xuxian Chen, Huijuan Qiu, Yuming Rong and Liangping Xia
Background: The effectiveness of Bevacizumab has been demonstrated for the treatment of metastatic colorectal cancer. However, the minimum number of bevacizumab cycles needed to improve overall survival is unknown. In addition, anti-angiogenic treatment has been shown in preclinical studies to accelerate metastasis. To investigate these two issues, we performed a retrospective case-control study in Chinese patients with metastatic colorectal cancer.
Methods: Patients initially diagnosed as metastatic colorectal cancer at the Sun Yat-sen University Cancer Center from 2004 to 2010 were recruited. All patients treated with bevacizumab served as experimental group; patients not treated with bevacizumab were control group. The primary endpoints were overall survival and the incidence of new metastatic lesions in the liver and other organs.
Results: Patients received more than 4 cycles of be.. View More»