Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
+44 1223 790975
ISSN: 2167-7700
+44 1223 790975
Bakshi Bhavagaya
United Kingdom
Research Article
Assessing the Value of Weekly Full Blood Counts in Patients with Gynecological Cancers Receiving Weekly Carboplatin/Paclitaxel Chemotherapy
Author(s): Marcia Hall, Danny Ulahannan, Naiome Carter, Bakshi Bhavagaya and Gordon RustinMarcia Hall, Danny Ulahannan, Naiome Carter, Bakshi Bhavagaya and Gordon Rustin
Background: Dose dense carboplatin and paclitaxel regimens are increasingly being used to treat advanced serous gynaecological malignancies (ovary and uterus) in the adjuvant and relapse setting. The purpose of this study was to quantify the incidence of neutropenia and thrombocytopenia in patients receiving weekly Carboplatin and Paclitaxel (wCP) or Carboplatin q21 with weekly Paclitaxel (CwP) and more specifically the incidence of clinically significant myelosuppression ? neutropenic sepsis or thrombocytopenia requiring intervention such as platelet transfusion. Our overall aim being to determine if routine blood counts are really necessary on days 8 and 15 of a wCP 21/28 day cycle or CwP 21 day cycle. Results: We analysed haematological data for 56 patients, 24 of whom had wCP and received 179 planned infusions and 32 of whom had CwP and received 407 planned infusions. The incidence o.. View More»
DOI:
10.4172/2167-7700.1000128