Rheumatology: Current Research
Open Access
ISSN: 2161-1149 (Printed)
ISSN: 2161-1149 (Printed)
Ayato Miyamoto
Japan
Research Article
Synovium in the Transitional Zone between the Articular Cartilage and the Synovial Membrane Contains Stem Cells and has Greater Chondrogenic Differentiation Potential than Synovium in Other Locations
Author(s): Nobuo Adachi, Ayato Miyamoto, Masataka Deie, Atsuo Nakamae, Tomoyuki Nakasa and Mitsuo OchiNobuo Adachi, Ayato Miyamoto, Masataka Deie, Atsuo Nakamae, Tomoyuki Nakasa and Mitsuo Ochi
Purpose: There were two aims of the present study. (i) to determine differences in chondrogenic potential between synovial cells located in the transitional zone between the articular cartilage and the synovial membrane and those cells in other locations and (ii) to determine the location of mesenchymal stem cells in the synovium.
Methods: Synovium was obtained from two different locations in 8-week-old male Sprague-Dawley rats. In Group A, the synovium was harvested from the transitional zone between the articular cartilage and the synovial membrane in the femoral condyle. In Group B, the synovium was harvested from an area 5 mm medial to the transitional zone of the femoral condyle. Synovial cells in both groups were isolated and cultured in monolayer culture system and the proliferation of cells in the first passage was compared between Gr.. Read More»
DOI:
10.4172/2161-1149.S3-001