Drug Designing: Open Access
Open Access
ISSN: 2169-0138
+19473334405
ISSN: 2169-0138
+19473334405
Ariaya Haymete
Ethiopia
Research Article
Synthesis and In-Vivo Pharmacological Evaluation of Some Novel 4(3H)- Quinazolinone Derivatives as Potential Anti-malarial Agents
Author(s): Mohammed Hussen Bule, Ariaya Haymete and Belayneh KefaleMohammed Hussen Bule, Ariaya Haymete and Belayneh Kefale
In this work six 3-aryl-2-(substituted styryl)-4(3H)-quinazolinones derivatives were synthesized by the reaction of 3-aryl-2-methyl-4(3H)-quinazolinone (intermediate products) with different substituted aromatic aldehydes. Three intermediate products were synthesized by reacting 2-methyl-3,1-benzoxazin-4-one, which was initially prepared by cyclizing anthranilic acid using acetic anhydride, with three aromatic amines. Their structures were confirmed using IR, 1HNMR, 13CNMR spectroscopic methods and elemental microanalyses. The synthesized compounds were evaluated for their in vivo antimalarial activity against P. berghei. Four of the synthesized compounds (IIIc, IVa, IVb and IVf) exhibited activity against the parasite. Among these compound IVa was found to be the most active compound. Results of acute toxicity study showed that oral administration of the synthesized compounds in sing.. Read More»
DOI:
10.4172/2169-0138.1000121