Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Anja Jochmann
University Hospital for Children (UKBB), Departments of Pediatrics and Infectious Diseases, Spitalstr 33, 4056 Basel,
Switzerland
Research Article
Correlation of Twenty Virulence Genes of Staphylococcus aureus with Severity of Atopic Dermatitis in Children as Compared to Healthy Individuals
Author(s): Anja Jochmann, Suzanne Hower, Stephen Davis, Jan Izakovic and Lisa RW PlanoAnja Jochmann, Suzanne Hower, Stephen Davis, Jan Izakovic and Lisa RW Plano
Principles: Patients with Atopic Dermatitis (AD) have a higher susceptibility for colonization and infection with Staphylococcus aureus. Virulence factors of S. aureus may modulate the host immune response and affect the clinical course of infection.
Methods: Bacterial cultures were obtained from AD patients and uninfected controls. PCR and DNA sequence analysis were used to determine microbial surface components recognizing adhesive matrix molecules (MSCRAMM) patterns, staphylococcus protein A (spa) types, and the presence of genes for 20 virulence factors and for methicillin resistance (mecA). Virulence factor gene patterns from AD associated S. aureus were compared with gene patterns from the control group, as well as with S. aureus previously obtained from infected skin lesions not associated with AD.
Results: .. View More»
DOI:
10.4172/2155-9554.1000174