Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Ana Maria Abreu Velez
M.D, Ph.D, Georgia Dermatopathology Associates, 1534 North Decatur Rd., NE; Suite 206, Atlanta, Georgia 30307-1000,
Tanzania
Case Report
Jam-A, Plasminogen and Fibrinogen Reactivity in a Case of a Lupus Erythematosus-Like Allergic Drug Reaction to Lisinopril
Author(s): Ana Maria Abreu Velez, A. Deo Klein and Michael S. HowardAna Maria Abreu Velez, A. Deo Klein and Michael S. Howard
Background: Drug-induced lupus erythematosus is a lupus variant that resolves within days to months after withdrawal of the eliciting drug, in patients without other major underlying immune system dysfunction. Case report: A 71 year old Caucasian female presented following sudden onset of an erythematous, desquamative, polycyclic, scaling and pruritic rash in sun exposed areas, 4 days after taking Lisinopril®. Skin biopsies for hematoxylin and eosin analysis, as well as for direct immunofluorescence (DIF) were obtained. Results: The hematoxylin and eosin staining revealed basal layer vacuolar degeneration, basilar apoptotic and dyskeratotic keratinocytes, and a lymphocytic interface dermatitis with an additional superficial and deep, perivascular and periadnexal lymphohistiocytic infiltrate. A significant presence of .. View More»
DOI:
10.4172/2155-9554.S6-004