Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Amit Ahuja
HERON: A PAREXEL Company,
3rd Floor, DLF Tower E, Rajiv Gandhi IT Park, Chandigarh - 160101, UT
India
Research Article
Systematic Review and Indirect Treatment Comparison of Dabrafenib and Trametinib versus Other Treatments Used in Previously Untreated Metastatic Melanoma Patients
Author(s): Kunal Srivastava, Mayur M Amonkar, Amit Ahuja, Ceilidh Stapelkamp, Suzanne Swann, Michelle Casey and Cheena RanaKunal Srivastava, Mayur M Amonkar, Amit Ahuja, Ceilidh Stapelkamp, Suzanne Swann, Michelle Casey and Cheena Rana
Objectives: A systematic literature review was undertaken with quantitative analysis, including meta-analysis and Bucher-adjusted indirect treatment comparisons (ITCs), to evaluate efficacy, safety, and tolerability of dabrafenib and trametinib monotherapy versus other first-line metastatic melanoma (MM) treatments.
Methods: Embase®, MEDLINE®, CCTR, and key conferences were searched through October 2012 for relevant randomized controlled trials. Using a random-effects network meta-analysis, dabrafenib and trametinib were compared directly versus dacarbazine (DTIC) and indirectly versus ipilimumab plus DTIC, temozolomide, and vemurafenib. A Rank Preserving Structural Failure Time Method was used to adjust overall survival (OS) estimates in studies that allowed treatment crossover upon progression.
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DOI:
10.4172/2155-9554.10000294