Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Alcira M. Del C. Batlle
Viamonte 188l 10º “A”, C1056ABA - BUENOS AIRES,
Argentina
Case Report
Identification of CYP3A5 and CYP2B6 Polymorphisms in Porphyria Cutanea Tarda Associated to Human Immunodeficiency Virus
Author(s): Jimena V. Lavandera, Victoria E. Parera, Maria Victoria Rossetti, Alcira M. Del C. Batlle and Ana Maria BuzalehJimena V. Lavandera, Victoria E. Parera, Maria Victoria Rossetti, Alcira M. Del C. Batlle and Ana Maria Buzaleh
To date, few or no data concerning the prevalence of polymorphisms in drug metabolism genes of antiretroviral drugs have been reported in the Argentinean population or in porphyric individuals worldwide. The purpose of the current investigation was to determine whether interindividual differences in cytochrome P450 3A5 (CYP3A) and 2B6 (CYP2B6) genes could influence the triggering of Porphyria Cutanea Tarda (PCT) in subjects with human immunodeficiency virus (HIV) after antiretroviral exposure.
A total of 141 subjects, 60 control volunteers and 81 unrelated individuals with PCT were included in the study. In the porphyric group, 21 individuals were HIV positive. To evaluate the presence of the alleles CYP3A5*3, CYP3A5*6 and CYP2B6*6 a polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis was performed.
The frequencies of CYP3.. View More»
DOI:
10.4172/2155-9554.S2-006