Rheumatology: Current Research
Open Access
ISSN: 2161-1149 (Printed)
+44-20-4587-4809
ISSN: 2161-1149 (Printed)
+44-20-4587-4809
Adam W Pierzchala
Sport-Clinic Scanmed Multimedis Group, Klinika Chirurgii Endoskopowej,
Poland
Research Article
Expression of IL-1β Receptor Antagonist in Patients with Severe Osteoarthritis of the Knee–The Mechanism Limiting the Inflammation in Osteoarthritis
Author(s): Adam W PierzchalaAdam W Pierzchala
Introduction: Expression of interleukin-1β (IL-1β) in the synovial fluid of patients with osteoarthritis has been confirmed. The overall effect of this cytokine can be described as a chondrocyte-dependent cartilage destructive potential. The interleukin-1β receptor antagonist (IL-1Ra) blocks the interaction between IL-1β and its receptor on the cell surface. Human chondrocytes and synoviocytes produce IL-1Ra in a response to stimulation by IL-1β and IL-6. The local production of IL-1Ra in the joint has a protective effect against the catabolic action of IL-1β.
Material and Methods: Synovial fluid and blood serum were obtained from 31 patients undergoing knee replacement surgery because of osteoarthritis. For comparison, samples were obtained from another 30 patients during diagnostic or therapeutic arthroscopy p.. View More»
DOI:
10.4172/2329-8731.1000217