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Journal of Cell Signaling

Journal of Cell Signaling
Open Access

ISSN: 2576-1471

Abril Saint-Martin

Abril Saint-Martin

Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

Biography
During the postdoctoral research fellowship, I develop a project about the effects of stable knockdown of HIF-1  or HIF-2 in advanced CRC, using cell lines. We found that malignant cells exhibit high basal levels of autophagy and the HIFs proteins, compared with control non-malignant cells. HIFs depletion alone resulted in increased autophagic and apoptotic cell death, indicating that survival of colon cancer cells is HIF-dependent.

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