Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Abdul Latif
Pakistan
Research Article
Broad Spectrum Anticancer Activity of Pistagremic Acid
Author(s): Ghias Uddin, Abdur Rauf, Bina Shaheen Siddiqui, Ajmal Khan, Bishnu P Marasini, Abdul Latif and Thomas J SimpsonGhias Uddin, Abdur Rauf, Bina Shaheen Siddiqui, Ajmal Khan, Bishnu P Marasini, Abdul Latif and Thomas J Simpson
Background: Pistagremic acid; 3-methyl-7-(4,4,10,13,14-pentamethyl-3-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthr-en-17-yl)-oct-3-enoic acid was isolated from the chloroform fraction of Pistacia integerrima. Cytotoxic evaluation against NCI-60 DTP human tumor cell line was performed. Methods: The anticancer assays for this compound were performed in accordance with the protocol of the Drug Evaluation Branch, by the National Cancer Institute (NCI) Developmental Therapeutic Program (www.dtp.nci.nih.gov) to be screened for their anticancer activity in vitro. Results: It showed broad spectrum antiproliferative activity with an average GI50, and TGI, values 0.103 μM and 0.259 μM, respectively. It also showed significant LC50 value at the average 0.634 μM against all cell lines excluding K-562, RPMI-8226, NCI-H226, and NCI-H460 cell-lines. Conclusion.. View More»
DOI:
10.4172/2167-7700.1000117