Virology & Mycology
Open Access
ISSN: 2161-0517
ISSN: 2161-0517
G V Reva, I A Khramova, S A Nikolaenko, Yu P Nedobilskaya and I V Reva
Far Eastern Federal University, Russia
Pacific State Medical University, Russia
Regional Clinical Center of Specialized Types of Medical Care, Russia
Posters & Accepted Abstracts: Virol Mycol
Summary: The conducted research established that local application of Chitosan gel incorporated with Tinrostin at 73.4% of women is conducted to elimination of the human papillomavirus and regression of atypical changes in the mucous vaginal part of the cervix, although modern methods of diagnosis and treatment of precancerous cervical disease cervical cancer continues to grow. One of the most important factors in carcinogenesis is persistence of oncogenic types of human papillomavirus (HPV). When cervical dysplasia outlook is favorable, provides the human papilloma virus excretion from the body. Objective: To compare the effectiveness of treatment unexpressed atypical changes in cervical squamous (ASCUS (atypical squamous cells of undetermined significance), by Terminology System for Bedesten, 2001), squamous intraepithelial lesions of low grade (LSIL) associated with the papillomavirus infection, Izoprinozine known drug and Chitosan gel incorporated with Tinrostin made of marine aquatic. Method: The study is based on data obtained during the examination and treatment of 42 women in Vladivostok of 25-35 years of age living with high oncogenic risk HPV. Standard survey included examination of the cervix and vaginal walls in the mirror under the control of extended colposcopy, cytology smear from the cervix and HPV testing. The group studied included only those women who, in addition to detection of high risk HPV types were not expressed atypical epithelial changes of the cervix and squamous intraepithelial lesions of low degree (ASCUS and LSIL). Result: Group-1 included 18 women treated with immunomodulator Isoprinosine 2 tablets (1000 mg) 3 times a day. Group-2 consisted of 24 women who underwent local treatment with Chitosan gel incorporated with Tinrostin. Treatment was carried out within 3 months as courses. Overall efficacy was evaluated twice at 3 and 6 months. The clinical effect was observed in the same way in both groups of women (56.7%). Exocervix defeat was disappeared, colposcopic picture was normalized, advancing regression altered cytologic picture. The elimination of HPV in women��?s group-1 was observed in 62.1% of cases, the elimination of HPV in women��?s group-2 was observed in 73.4% of cases. Conclusion: Local application of Chitosan gel incorporated with Tinrostin is a promising treatment for women with cervical disease associated with the papillomavirus infection caused by high risk HPV.
Email: revagal@yandex.ru