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Posters: Transl Med
Gaucher disease is caused by defective human glucocerebrosidase. This disease can be classified according to the symptomatic states in 3 types. One has the acute neurodegenetion. However, the molecular mechanism of Gaucher disease is totally unknown. To address the molecular mechanism, we generated Drosophila lines overexpressing human normal and mutated glucocerebrosidase gene (R120W, L444P+A456P+V460V) in the eyes using GMR-GAL4 driver. Three lines of mutated transgenic flies showed defective morphology in Drosophila eyes. Here, we present the data showing a new molecular mechanism of Gaucher disease by using Drosophila model. Furthermore, I talk about the way to prevent the neurodegeneration of Gaucher disease.
Takahiro Suzuki has completed his Ph.D at the age of 32 years from Tsukuba University.