Virology & Mycology
Open Access

The effect of virus on diabetes mellitus

11^th world congress on virology and Infectious diseases

May 17-18, 2018 Tokyo, Japan

Soumik Laha

Maulana Abul Kalam Azad University of Technology, India

Posters & Accepted Abstracts: Virol Mycol

Abstract :

Diabetes mellitus is a group of metabolic disease which caused due to defects of insulin secretion. According to new research several viral infections can develop diabetes. Mainly the virus can attack �?²-cells and affected the pancreatic cells for insulin secretion. Several types of virus like enteroviruses, Rubella virus, Coxsackievirus B (CVB), Cytomegalovirus (CMV), Epstein-Barr virus, Mumps virus, Varicella zoster virus have been suggested to be associated with type-1 diabetes. Among them enteroviruses are more susceptible to increase type-1 diabetes. Enteroviruses target �?²-cells through surface molecules. Virus infections attacked on �?²-cells and promote strong inflammations in islets. Viral infections unmask the �?²-cells and cause up-regulation of MHC class I molecules on �?²-cells. When �?²-cells are damaged and APCs uptake auto-antigen then initiation of autoimmunity occurs. Type 1 Diabetes occurs when 90% of B cells are damaged. If virus attacks the �?²-cells and manages to destroy the cells, then there is a high chance of diabetes. From another research, some viruses contain protein that can mimic insulin and can produce insulin like hormone which can cause diabetes. So, the virus infections have a strong influence in diabetes mellitus. soumikrx@gmail.com