T cell immune response in influenza infection | 3366
Virology & Mycology

Virology & Mycology
Open Access

ISSN: 2161-0517

+44 1223 790975

T cell immune response in influenza infection

International Conference on Flu

June 08-10, 2015 Chicago, USA

Sneha Shekhar1 and Sumit Sahu2

Posters-Accepted Abstracts: Virol-mycol

Abstract :

Influenza infection invokes innate and adaptive immune responses in order to protect host against viral/bacterial infection. Upon infection virus-specific T cell responses are induced, including CD4+ T helper cells and CD8+ cytotoxic T cells,Memory CD4 and CD8 T cells are generated in response to viral infection. Influenza virus evade antibody-based vaccines, and memory CD4 T cells in anti-viral immunity helps in the development of broad-based T cell-mediated immunity that will provide protection against influenza infection with variant or new influenza virus strains that affect the public health. In the periphery and lung of children and adults memory CD4 T cells directed against influenza infection with the potential to mediate �??firstline�?� immunity to viral challenge, particularly at the site of infection. CD4 T cells are typically classified into different subsets based upon cytokine expression. By analyzing pre-committed population of T helper cells can lead to a wider understanding of the mechanisms and it might control the regulation of heterogeneity in cytokine patterns displayed because of pathogen challenges. The influenza virus induces chemokine and cytokine production by infected epithelial cells, monocytes and macrophages,which leads these chemokine to attract immune cells to the site of infection, including macrophages, neutrophils and natural killer (NK) cells.