University Malaya Medical Centre, Malaysia
Posters & Accepted Abstracts: Clin Exp Ophthalmol
Introduction & Objective: In the new era of modern technology, the introduction of antiretroviral therapy has markedly lower
down the prevalence of retinal Opportunistic Infections (OIs) in HIV infected patients. However, despites of absence retinal
OIs, studies have proven abnormalities in visual function in HIV infected individuals. In this study, we aim to analyze the
Retinal Nerve Fibre Layer (RNFL) thickness in HIV patients who are on antiretroviral treatment in Malaysian adults.
Method: In this case control study 202 HIV infected individuals without retinal OIs and 129 HIV seronegative individuals age matched were enrolled. RNFL thickness was measured with spectral domain coherence tomography in four quadrants. All significant variables were analyzed using statistical tests to identify significant correlation.
Results: A total of 331 individual were recruited for this study, 202 patients were HIV infected individuals and 129 were HIV seronegative individuals. For RNFL thickness, univariate analysis showed a statistically significant difference between the case and control group in the temporal quadrant (69.03 μm vs 73.14 μm, p=0.008).
Conclusion: There are significant differences in the RNFL thickness of the HIV infected individuals compared to healthy controls. From the study the difference is maintained in the RNFL temporal quadrant after adjusting for potential cofounders.
Nilani MN has completed her MBBS Malaya from University Malaya, Malaysia. She is currently pursuing her Masters in Ophthalmology at University Malaya, Malaysia.