Phospholipase Cγ1 links inflammation and tumorigenesis in | 8452
Translational Medicine

Translational Medicine
Open Access

ISSN: 2161-1025

+44 1223 790975

Phospholipase Cγ1 links inflammation and tumorigenesis in colitis-associated cancer

14th Annual Conference on Translational Medicine and Oncologists Meet

November 28-30, 2016 San Francisco, USA

Kwangil Park

Korea Institute of Oriental Medicine, Republic of Korea

Posters & Accepted Abstracts: Transl Med

Abstract :

Colorectal cancer is linked to inflammation and phospholipase C 1 (PLC �?³1) is associated with tumorigenesis and the development of colorectal cancer; however, evidence of mechanisms connecting them remains unclear. Here we found that PLC �?³1 regulated colitis and tumorigenesis in intestinal epithelial cells (IEC). In a colitis-associated cancer model, we showed that the deletion of PLC �?³1 in IEC decreased the incidence of tumors by enhancing apoptosis and inhibiting proliferation during tumor development. Accordingly, the deletion of PLC �?³1 in IEC reduced colitis-induced epithelial inflammation via inhibition of pro-inflammatory cytokines and mediators. The PLC �?³1 pathway in IEC accelerated colitis-induced epithelial damage via regulation of tight junction (TJ) proteins. Our findings suggest that PLC �?³1 is a critical regulator of colitis and colorectal cancer and could further help in the development of therapy for colitis-associated cancer.

Biography :

Kwangil Park has been conducted the “An effect of anti-inflammatory and anti-cancer by natural products”. He investigated the compounds and extract isolated from natural products modulate on transcription and translation pathway, and using the mechanism underlying its action.