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PapU29 study: New strategy for cervical cancer screening using an urine HPV testing in general population, cost-effectiveness in 341,534 non-attendees women
Virology & Mycology

Virology & Mycology
Open Access

ISSN: 2161-0517

PapU29 study: New strategy for cervical cancer screening using an urine HPV testing in general population, cost-effectiveness in 341,534 non-attendees women


6th Euro Virology Congress and Expo

March 10-12, 2016 Madrid, Spain

Christopher Payan

Brest University Hospital, France

Posters & Accepted Abstracts: Virol-mycol

Abstract :

The PapU29 study was designed as an alternative strategy for cervical cancer screening. In Europe, cytology-based screening coverage varies from 40-80%; it is around 55% in France and down to 25% in some areas. The aim of screening programs is to reach 80% coverage. Since Human Papillomavirus (HPV) is found in almost all cervical cancer and pre cancer lesions, screening strategies based on HPV testing are proposed. To facilitate access to these tests, vaginal self-sampling has been largely studied. Therefore, we developed an urine HPV test, with more than 80% concordance with cytology and vaginal self-sample testing. Our urine HPV test has been proposed at home in Finist√?¬®re to 12,498 non-attendees women, with no cytology over 3 years (2008-2010); among them 3078 (28%) sent by mail their urine sample to our lab for testing; 764 (28%) were found HPVpositive and 51 among them had abnormal cytology (8%) with 12 pre cancer CIN2+ lesions and 1 cervical cancer (1/5000 expected). A five year follow-up showed no pre cancer lesions in urine HPV-negative women (n=687). All cancer and pre cancer women were treated and no relapse was observed. Evaluation of this strategy in Finist√?¬®re (n=124,279) and Gironde (n=217,255), west and southwest areas in France, avoided cancer accounted to 5.5 and 31.5 in the cytology group and the urine HPV group respectively, costs per screened CIN2+ woman would be 44,879√ʬ?¬¨ and 16,910√ʬ?¬¨ respectively in these groups. This cost could be reduced to 7424√ʬ?¬¨ if the urine HPV strategy is restricted to 35-49 old women.

Biography :

Email: [email protected]

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