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Tsegaye Melaku Kebede, Girma Mamo, Legese Chelkeba and Tesfahun Chanie
Jimma University, Ethiopia
Scientific Tracks Abstracts: J Clin Trials
Background: The life expectancy of people living with human immunodeficiency virus (HIV) has dramatically improved with the much increased access to antiretroviral therapy. Consequently, a larger number of people living with HIV are living longer and facing the increased burden of non-communicable diseases. Objective: To assess effect of chronic diseases comorbidities and determinants of treatment outcomes among HIV infected patients on highly active anti-retroviral therapy at Jimma University Specialized Hospital. Methods: A nested case-control study was conducted among people living with HIV at Jimma University Specialized Hospital from February 20 to August 20, 2016. Patient specific data was collected using structured data collection tool to identify relevant information and also patient reported outcome quality of life-HIV (PROQOL-HIV) scale was used to assess health related quality of life of patient. Data was analyzed using statistical package for Social Science version 20.0. Logistic and linear regressions were done to identify factor associated to outcomes. Statistical significance was considered at p-value <0.05. Results: A total of 160 participants, 80 cases and 80 controls were included in the analysis. Among cases; hypertension accounts 13.8%, followed by diabetes (11.9%) and about 12.5% had multimorbidity. At baseline, the mean (�?±SD) age of cases was 42.32�?±10.69 years, whereas it was 38.41�?±8.23 years among controls. The median baseline CD4+ cell count was 184.50 cells/�?¼L (IQR: 98.50-284.00 cells/�?¼L) for cases and 177.0 cells/�?¼L (IQR: 103.75-257.25 cells/�?¼L) for controls. Post 6-months of highly active anti-retroviral therapy initiation, immunologic failure was 28.80% among cases and it was 16.25% among controls. An average increase of CD4+ cell count was 6.4 cells per �?¼L per month among cases and 7.6 cells per �?¼L per month among controls. The mean�?±SD score of health related quality of life among cases was 57.39�?±6.89, 73.52�?±13.22, 64.15�?±9.03, 81.37�?±8.31 and it was 71.74�?±21.64, 76.48�?±11.88, 67.25�?±9.67, 81.53�?±8.08 among controls in physical health and symptoms, health concerns and mental distress, social and intimate relationships, treatment-related impact dimension respectively. Male sex [AOR, 3.51; 95% CI, 1.496 to 8.24; p=0.004], smoking history [AOR, 2.81; 95% CI, 1.072, to 7.342; p=0.036] and comorbidity with noncommunicable chronic diseases [AOR 3.99; 95% CI, 1.604 to 9.916; p=0.003)] are independent predictors of immunologic failure. Conclusions & Recommendations: Chronic non-communicable diseases have negative effects on the kinetics of CD4+ cell count and also have negative impact on quality of life among HIV-infected patients who initiated antiretroviral therapy. So integration of chronic non-communicable disease-HIV collaborative activities will strengthen battle to control double burden of chronic illnesses.
Tsegaye Melaku Kebede is a Lecturer and Clinical Pharmacist at School of Pharmacy, Institute of Health Sciences, Jimma University, Ethiopia. His interests span across enhancing his capacity through continuing education and solving health care problems of his community.