Journal of Clinical and Experimental Ophthalmology
Open Access

New insights in the pathogenesis of retinal vein occlusions

5^th International Conference on Clinical & Experimental Ophthalmology

August 04-06, 2015 Valencia, Spain

Maneli Mozaffarieh

Scientific Tracks Abstracts: J Clin Exp Ophthalmol

Abstract :

The pathogenesis of the condition remains to be solved. Mechanical compression of the vessel wall or thrombotic occlusion of
the vessel lumen sometimes, combined with rheological disorders are often assumed mechanisms. Accordingly, the therapy
also either relies on mechanical decompression, lysis of thrombi or improvement of the rheology. Yet whilst the pathophysiological
concepts described in the literature so far covers some aspects of the disease, they do not sufficiently explain all the phenomena. A
number of observations as for example the occurrence of RVO in younger patients without any signs of atherosclerosis, spontaneous
reversibility particularly in young patients, occlusion despite anticoagulation or thrombocytopenia and finally the positive effect of
anti-VEGF therapy are not explained by the present pathogenetic concept. As a new concept we previously proposed a local venous
constriction induced by vasoactive molecules diffusing from neighboring diseased arteries and/or from neighboring (hypoxic) tissues.

Biography :

Maneli Mozaffarieh is a Glaucoma Specialist working at the University of Basel, Department of Ophthalmology. The focus of her research is on ocular blood flow.