Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Lina Huang
Jinan University, China
Posters & Accepted Abstracts: J Clin Exp Ophthalmol
As an important component for the micro-environment, nerve growth factor (NGF) is an endogenous signal protein that can promote growth and proliferation of nerve. NGF is the earliest clearly discovered and discussed neurotrophic factor, it can maintain and promote the survival, growth, differentiation and executive function of the sympathetic nerve and sensory nerve cells from neural crest in central and peripheral nervous system, promoting the regeneration of the injured neurons. In addition, it is also involved in the regulating functions of immune, blood, endocrine and reproductive system. NGF functions by selectively combining with two kinds of specific target cell surface receptor- tyrosine kinase receptor (Trk A) or P75. There are two kinds of transportation of NGF: Anterograde along the axon to influence target cells, which is advantageous to transport the exogenous NGF to the damaged target Cell; and retrograde along the axon to influence its superior neurons. There are many optic nerve injury diseases or RGCs apoptosis diseases, such as glaucoma, diabetic retinopathy, retinitis pigmentosa, anterior ischemic optic neuropathy, optic nerve contusion, optic neuritis, etc. NGF plays with indications in this area. NGF functions in the development, differentiation, maturation of all layers of retina, and plays an important role in maintaining normal retinal physiological function. Studies have shown that application of exogenous nerve growth factor do protect optic nerve. When exogenous NGF is applied into the body, its activity and effects is related to drug delivery pathway and dosage. At present people do not think it directly effects on nerve cells, but forms complex with receptors and retrograde transport to recover damaged nerve.
Email: lina_h@126.com