Journal of Clinical and Cellular Immunology
Open Access

Multiple functions of immunoglobulins in the circulations

6^th International Conference and Expo on Immunology

October 24-26, 2016 Chicago, USA

Roald Nezlin

Weizmann Institute of Science, Israel

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

Immunoglobulin molecules perform many functions which are most important for immunity like combining with various antigens with the formation of immune complexes and activation of complement pathway. Serum contains thousands proteins of various origin and properties, synthesized by cells of liver, spleen and other organs and also traces non-self proteins of bacteria and virus origin. Immunoglobulins possess considerable reactivity and form non-immune complexes with many various proteins in the circulation. Immunoglobulin molecules can serve as scavengers removing proteins which are potentially harmful for the body. A good example of this function is the formation of stable IgG complexes with anaphylatoxins, proteins that are responsible for inflammatory and anaphylactoid reactions leading to various pathologies. More non-immune complexes were described with various activities. For example, some of them can stimulate lymphocytes while others could prevent the interactions of immunoglobulins with cell receptors.

Biography :

Email: roald.nezlin@weizmann.ac.il