Molecular detection of Human cytomegalovirus (HCMV) among congeni | 6096
Virology & Mycology

Virology & Mycology
Open Access

ISSN: 2161-0517

+44 1223 790975

Molecular detection of Human cytomegalovirus (HCMV) among congenital infants in Khartoum state, Sudan

6th Euro Virology Congress and Expo

March 10-12, 2016 Madrid, Spain

Khalid Abdallah Mohammed Enan

The Ministry of Higher Education and Scientific Research, Sudan

Posters & Accepted Abstracts: Virol-mycol

Abstract :

Human cytomegalovirus (HCMV) infection still represents the most common with potentially serious viral complication in humans and is a major cause of congenital anomalies��? in infants. This study was aimed to detect HCMV in infants with congenital anomalies. Study subjects consisted of infants born with neural tube defect, hydrocephalus (HC) and microcephaly. Fifty serum specimens (20 males, 30 females) were collected from different hospitals in Khartoum state. The sera were investigated for Cytomegalovirus specific immunoglobin M (IgM) antibodies using enzyme-linked immunosorbent assay (ELISA) and for Cytomegalovirus DNA using polymerase chain reaction (PCR). Out of the 50 sera tested, one patient��?s (2%) sample showed HCMV IgM but with no detectable DNA by using PCR, another 4 (8.2%) sera were positive for HCMV DNA by using PCR but with no detectable IgM using ELISA. Various diagnostic techniques should be considered to evaluate HCMV disease and routine screening for HCMV should be introduced for pregnant women in this setting. It is vital to initiate further research work with many samples from different area to assess prevalence and characterize HCMV and evaluate its maternal health implications.

Biography :