Virology & Mycology
Open Access
ISSN: 2161-0517
ISSN: 2161-0517
Zhanqiu Yang, Qiang Liu, Moli Hua, Yuanyuan Liu and Hairong Xiong
Wuhan University, China
Posters & Accepted Abstracts: Virol Mycol
Introduction & Aim: Jiawei-Yupingfeng-Tang (JYT) is a Chinese herbal formula which is widely used against respiratory tract illness. However, its effect against respiratory virus remains unknown. Influenza virus (IFV) and human respiratory syncytial virus (HRSV) cause million cases of severe illness per year and many of them developing into lethal pneumonia. The aim of this study is to evaluate whether JYT can be used in the treatment of such infections. Methods: The effect of the JYT against IFV and HRSV was tested by plaque reduction assay in the cell lines A549. The expression of ICAM-1 was determined by real-time RT-PCR and Western blot. A lethal influenza infected mice model developing into interstitial pneumonia was used to evaluate the effect of JYT in vivo. Results: JYT extract dose-dependently inhibited both IFV and HRSV when given before, simultaneous and after viral infection and it was more effective to block the entry of virus. Furthermore, pre-treatment with JYT can reduce the susceptibility of cells to the invasion of HRSV by inhibiting the expression of ICAM-1. Importantly, JYT extract increased the survival rate of lethal influenza-infected mice, prolonged survival time and alleviated the virus-induced lung lesion, which is compatible with that of ribavirin treatment. Conclusion: These data support JYT as an alternative modality to be used in the treatment of respiratory viral infection induced by HRSV and IFV.
Zhanqiu Yang has completed his MD from Wuhan University School of Medicine. He is the Director of Institute of Medical Virology, Wuhan University. He has published more than 150 papers in reputed journals and has been serving as an Editorial Board Member of repute.
Email: zqyang@whu.edu.cn