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Intraoperative corneal thickness changes during pulsed accelerate | 53610
Journal of Clinical and Experimental Ophthalmology

Journal of Clinical and Experimental Ophthalmology
Open Access

ISSN: 2155-9570

+44 1223 790975

Intraoperative corneal thickness changes during pulsed accelerated corneal cross linking using isotonic riboflavin with HPMC


International Conference and Expo on Cataract and Optometrists Meeting

August 04-05, 2016 Manchester, UK

Nihal Abdel Fatah Elghryany, Yehia M Salah El-Din, Ahmed M Sherif, Lamiaa S Aly, Amr A Osman, Michael A Grentzelos and George D Kymionis

Cairo University, Egypt
University of Crete, Greece
University of Miami, USA

Posters & Accepted Abstracts: J Clin Exp Ophthalmol

Abstract :

Purpose: To evaluate corneal thickness changes during pulsed accelerated corneal crosslinking (CXL) for keratoconus using a new isotonic riboflavin formula. Setting: eyeCare Center, Maadi, Cairo Methods: In this prospective, interventional, clinical study patients with grade 1-2 keratoconus (Amsler-Krumeich classification) underwent pulsed accelerated (30mW/cm2) CXL after application of an isotonic riboflavin solution (0.1%) with HPMC for 10 minutes. Central corneal thickness (CCT) measurements were taken using ultrasound pachymetry before and after epithelial removal, after riboflavin soaking and immediately after completion of UVA treatment. Results: Twenty eyes of 11 patients (4 male, 7 female) were enrolled. Mean patient age was 26�?±3 (range from 18 to 30 years). No intra-operative or postoperative complications were observed in any of the patients. Mean CCT was 507�?±35�?¼m (range 559-459�?¼m) before and 475�?±40�?¼m (range 535-420�?¼m) after epithelial removal (P<0.001). After 10 minutes of riboflavin instillation, there was a statistically significant decrease of CCT by 6.2% from 475�?±40�?¼m (range 535-420�?¼m) to 446�?±31�?¼m (range 508-400) (P<0.005). There was no other statistically significant change of CCT during UVA irradiation. Conclusions: A significant decrease of corneal thickness was demonstrated during the isotonic riboflavin with HPMC application while there was no significant change during the pulsed accelerated UVA irradiation.

Biography :

Email: nihalelghryany@hotmail.com

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