Virology & Mycology

Virology & Mycology
Open Access

ISSN: 2161-0517

+32-466-901905

Inhaled IFN-1b for RSV bronchiolitis


6th Euro Virology Congress and Expo

March 10-12, 2016 Madrid, Spain

Shen Kunling

Capital Medical University, China

Scientific Tracks Abstracts: Virol-mycol

Abstract :

Respiratory syncytial virus (RSV) is the most common pathogeny of bronchiolitis and 90% children are infected with RSV in their first 2 years. Interferon-α1b is the main subtype of alpha interferon in Chinese and has been widely used in viral disease treatment. A series of preclinical and clinical studies were carried out to evaluate efficacy and safety of IFN-α1b against RSV by aerosol inhalation. Animal PK and tissue distribution study demonstrates that after administration via aerosol inhalation, large amount of 125I-IFN-α1b concentrates in airway and stays longer than intramuscular injection. In a PD study, RSV infected mice which receiving inhaled IFN-α1b treatment show less tissue damage and lower RSV load in lung and increased CD3+CD8+ lymphocyte level in peripheral blood compared with control group. Both anti-RSV and immunoregulation effects of IFN-α1b are in a dose-effect manner. In a multicenter RCT study recruiting 330 acute bronchiolitis children, the total improvement rates of nebulized IFN-α1b 2 μg/kg and 4 μg/kg were 92.3% and 95.0% respectively and significantly higher than control group (85.3%, P<0.05). The effect on symptoms improvement of higher dose group is better than lower dose. The efficacy of IFN-α1b is better when used in early stage of disease and for RSV positive children. Irritation symptoms and serious adverse reactions were not observed. In summary, inhaled IFN-α1b is effective and safe for anti-RSV bronchiolitis in children.

Biography :

Shen Kunling is the Professor, Doctoral Supervisor and Physician Director. She has studied as a Visiting Scholar in Switzerland Infectious Disease Control Center, Australia Sydney Alexander Children’s Hospital and Medical College of Wisconsin. She has been serving as the current Chinese Medical Association Pediatrics Chairman, Committee Member of the International Academy of Pediatrics, Committee Member of the Asian Academy of Pediatrics, Vice President of Pediatricians Branch of the Chinese Medical Association, Leader of Chinese Medical Association breathing professional team, Committee Member of the tenth Pharmacopoeia and Committee Member of Chinese Medical Association breathing surgeon branch.

Email: [email protected]

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