Impact of variation in regulatory region on gene expression | 3743
Transcriptomics: Open Access

Transcriptomics: Open Access
Open Access

ISSN: 2329-8936

+44 1223 790975

Impact of variation in regulatory region on gene expression

International Conference on Transcriptomics

July 27-29, 2015 Orlando, USA

San Ming Wang

Keynote: Transcriptomics

Abstract :

Promoter is the regulatory part of a gene. In promoters, the interactions between cis-regulatory elements, e.g., transcriptionfactor binding sites (TFBS), and trans-regulatory elements, e.g., transcription factors (TFs), spatially and temporally regulate gene expression to ensure homeostasis of biological functions. Alterations in promoter sequences can change cis-trans interactions resulting in modified gene expression, impacting downstream biological processes, and leading to the development of disease. In this workshop, I will give an introduction on the topic, show the data from my breast cancer studies, and then have a round table discussion/presentation for attendees to address the issue covering normal gene expression regulation, evolution conservation, alternation in disease, etc.

Biography :

San Ming Wang finished his Master of Medicine 1986 from Shandong Medical University, Jinan, China. He pursued Doctor of Medicine at Genetic Unit, Swiss Institute for Experimental Cancer Research (ISREC)/University of Lausanne, Switzerland. He worked as Assistant Professor from 2004-2009 at Northwestern University. Later he got appointed as Director for Center for Functional Genomics, ENH Research Institute (Now named NorthShore University Health System Research Institute). From October, 2010�??till date, he is working as an Associate Professor at Department of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Nebraska.